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. 2019 Feb 19;9:2314. doi: 10.1038/s41598-018-38294-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Progressive cone photoreceptor degeneration. (A–D) Immunostaining with CA of 3.5 month old control (A,C) and Dicer CKO (B,D) peripheral and central retinas. (E) Quantification of CA^+ve cone photoreceptors in 3.5 month old retinas. (F–G) Immunostaining for CA of 6 month old control (F) and Dicer CKO (G) retinas. (H) Quantification of CA^+ve cone photoreceptors in 6 month old retinas. (I) Average length of CA^+ve segments (IS + OS) in 3.5 month old retinas. (J) Graph showing the percentage of cones displaying long (>20 μm), medium (10–19.99 μm) and short segments (<10 μm) in control and Dicer CKO peripheral and central 3.5 month old retinas. (M,N) Toluidine blue staining of 4 month old control and Dicer CKO retinas. Green dashed circle indicate cone nuclei. White dashed circles indicate rod nuclei. (O) CA staining on Chrnb4-cre 4 month old retinas. OS: outer segments. IS: inner segments. ONL: outer nuclear layer. INL: inner nuclear layer. OPL: outer plexiform layer. GCL: ganglion cell layer. CA: cone arrestin. *Indicates p-value < 0.05. Mann-Whitney non parametric test was used. Error bars indicate standard error of the mean. Scale bar: 30 μm. Scale bar of insets: 10 μm.