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. 2019 Feb 19;9:2256. doi: 10.1038/s41598-019-38678-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Y27pPBHSA lowers portal pressure and hepatic vascular resistance without systemic effects in cirrhotic rats. Systemic and portal hemodynamics were analyzed in hypertensive BDL and CCl₄ cirrhotic rats using a single i.v. administration of Y27pPBHSA (1 mg/kg b.w) after 3 h, 6 h and 24 h. Portal pressure (A,B), hepatic vascular resistance (HVR) (C,D) and mean arterial pressure (MAP) (E,F) were investigated. Results are expressed as mean ± standard error of the mean (SEM); n = 6/group, *p < 0.05 and **p < 0.01 for Y27-pPBHSA-treated vs. non-treated cirrhotic rats. Abbreviations: HVR, hepatic vascular resistance; MAP, mean arterial pressure; BDL, bile duct ligation.