Figure 7.

MnTMPyP administration reveals that neural progenitor cell proliferation is ROS independent. A, Representative images of Ki67 and Sox2⁺ labeling in control_MnTMPyP (top) and IH_MnTMPyP (bottom) animals are shown. Blue channel depicts DAPI-labeled nuclei on left, red channel depicts Ki67⁺ labeling second from left, green channel depicts Sox2⁺ labeling second from right, and a merge is on the right. Scale bars, 100 μm. B–E, The proportion of Ki67⁺/Sox2⁺-colabeled cells (control_MnTMPyP, n = 5; IH_MnTMPyP, n = 6) was increased following IH_MnTMPyP in the SGZ (t_(6.773) = 3.390, p = 0.0122; B), yet no differences were observed in the hilus (t_(8.869) = 1.293, p = 0.2287; C), GCL (t_(5.953) = 0.0863, p = 0.9340; D), and ML (t_(8.532) = 0.6589, p = 0.5273; E). *p < 0.05.