Table 3.

Comparison of medicated versus unmedicated 22q11DS^a

	Antipsychotic		Stimulant
	t	p	t	p
Combined rs-fcMRI effects	−1.64	0.144	0.20	0.849
Thalamus-to-ROIa	−0.34	0.735	−0.58	0.581
Thalamus-to-ROIb	1.00	0.361	0.39	0.710
Hippocampus-to-ROIa	−0.56	0.603	−1.00	0.346
Hippocampus-to-ROIb	−1.13	0.302	0.60	0.565

^aFunctional connectivity scores for the subset of patients medicated with antipsychotics were compared with the rest of the 22q11DS patients (and similarly for 22q1DS with and without dopaminergic stimulants). Results are presented from two-sample t test, with the dependent variable considered as the linear combination of functional connectivity values from both seeds and ROIs. Combined rs-fcMRI effects, linear combination of connectivity values from the thalamus and hippocampus to the two ROIs (ROIa and ROIb) derived from the Type I error-protected Group × Seed interaction analysis (see Whole-brain seed-based functional connectivity analyses). The linear combination was obtained as follows: [thalamus-to-ROIa + hippocampus-to-ROIb] − [thalamus-to-ROIb + hippocampus-to-ROIa].