Figure 8.

Inactivation of the PL→avBST pathway with a different inhibitory opsin (Arch) increases passive, and decreases active coping behaviors. a, Illustration of AAV-Arch injection into PL and fiber placement above avBST for pathway inhibition during shock probe defensive burying test. Rats receiving inactivation with Arch exhibited increased immobility (b), and decreased burying behavior (c), relative to laser-stimulated YFP rats. d, Ancillary measures of ambulation (d), approach latency (e), rearing (f), and grooming (g) did not significantly differ as a function of experimental treatment. Data are shown as mean + SEM. *p < 0.05.