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. 2019 Feb 20;39(8):1484–1504. doi: 10.1523/JNEUROSCI.1685-18.2018

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Copyright © 2019 the authors 0270-6474/19/391485-21$15.00/0

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Figure 5. — Effects of 8-OH-DPAT-induced increases in the frequency and amplitude of spontaneous IPSCs in RGCs are blocked by WAY-100635. A, Recordings in a representative experiment. The top trace (a) is a recording of an RGC after preincubation with CNQX + AP5 showing that WAY-100635 prevented alterations of the frequency and amplitude of the spontaneous IPSCs induced by 8-OH-DPAT. Vertical bar, 20 pA; horizontal bar, 1 min. The bottom traces (b–e) show the recording of the RGC on an expanded time scale. b, Control condition; c, during WAY-100635 treatment application; d, during WAY-100635 + 8-OH-DPAT treatment application; and e, recovery. Vertical bar, 10 pA; horizontal bar, 0.2 s. B, C, Summarized data on the frequency (B) and amplitude (C) of spontaneous IPSCs (n = 11).