Table 1.

miRNA involved in BAT expansion.

miRNA	Effect in differentiation	Target gene	Obesity	Reference
miR-27	↓	Prdm16 Creb Pparα Pgc-1β	miR-27 expression correlates with BMI	Yu et al., 2018 Sun and Trajkovski, 2014
miR-34a	↓	Fgf21 Sirt1	miR-34a expression is increased in obesity. miR-34a overexpression protected against HFD-induced obesity	Fu et al., 2014
miR-133	↓	Prdm16	Antagonist miR-133 treatment protected against HFD-induced obesity	Yin et al., 2013
miR-155	↓	Cebpβ	miR-155 KO protected against HFD-induced obesity	Gaudet et al., 2016
miR-199a-214	↓	Prdm16 Pgc-1α	miR-199a-214 expression reduced in genetic models of obesity. Anti-miR-199a-214 injection protected against body weight gain	He et al., 2018
miR-328	↑	Bace1	HFD-induced obesity increased miRNA-328 expression in BAT	Oliverio et al., 2016
miR-378	↑	Pde1b	miR-378 promoted BAT expansion, protecting against genetic and HFD-induced obesity	Pan et al., 2014
miR-455	↑	Runxlt1 Necdin	miRNA-455 transgenic mice (FAT455) protected against HFD-induced obesity	Zhang et al., 2015
miR-93-106b	↓	Ppparα	HFD-induced obesity increased miRNA-93-106b expression in BAT	Wu et al., 2013

Role in obesity.