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. 2019 Feb 13;10:110. doi: 10.3389/fimmu.2019.00110

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Copyright © 2019 Fink.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration of the human (A) BCR and (B) TCR mRNA organization and approximate transcript length. Nucleotide values are estimates based on the amino acid lengths reported in: https://www.uniprot.org/uniprot. Ab heavy chain (HC) variable region: 110–120amino acids (aa). HC constant region for IgG1 isotype: 330aa, Ab light chain (LC) variable region: 110–120aa, LC constant region kappa: 107aa, lambda 106aa. TCRbeta and TCRalpha variable region: 110–120aa. TCRbeta constant region: 176aa, TCRalpha constant region: 140aa. The mRNA is assembled from one allele of the variable (V), diversity (D), and joining (J) genes, which are illustrated in red, blue, and green, respectively. CDR3, Complementarity-determining region 3. Schematic structures of the expressed BCR and TCR are shown on the right with the CDR3 spanning V(D)J sequence. In the real structures, the CDR3 loops are exposed at the tips of the BCR or TCR.