Figure 2.

Schematic of GPCR/EGFR-CARMA3 signaling pathway leading to NF-κB activation. In cancer cells and endothelial cells, stimulations of the surface receptor EGFR and GPCR trigger the proximal signaling, leading to activation of phospholipase C (PLC) and protein kinase C (PKC). The activated PKC further phosphorylates CARMA3 and enables CARMA3 to form the CBM complex through interaction with the downstream Bcl10 and MALT1. Formation of the CBM complex leads to activation of the IKK complex through NEMO polyubiquitination. Ub, ubiquitination; p, phosphorylation.