Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 13;10:176. doi: 10.3389/fimmu.2019.00176

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Zhang and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

CARMA3 Is a host factor regulating the balance of inflammatory and antiviral responses against viral infection. Upon RNA virus infection in airway epithelial cells, CARMA3 sequesters MAVS from forming high-molecular-weight aggregates, thereby suppressing TBK1/IRF3 activation. Following NF-kB activation upon virus infection, CARMA3 undergoes K48-linked ubiquitination and is targeted for proteasome-dependent degradation, which releases MAVS to activate IRF3.