Table 2.
Correlation coefficient (r) between the proportion of different interleukin (IL)‐17‐secreting CD4+ and CD8+ T‐cell subsets expressing Toll‐like receptors (TLRs) and clinical parameters in multiple sclerosis (MS) patients
| No. active brain lesions | EDSS | |||
|---|---|---|---|---|
| r | P | r | P | |
| % TLR‐2+ CD4+ T‐cells | ||||
| IL‐17+ IFN‐γ + | 0·9537 | <0·0001 | 0·5556 | 0·0110 |
| IL‐17+ IL‐6+ | 0·4798 | 0·0323 | 0·4553 | 0·0437 |
| IL‐17+ IL‐10+ | −0·035 | 0·8807 | −0·024 | 0·92 |
| % TLR‐4+ CD4+ T‐cells | ||||
| IL‐17+ IFN‐γ + | 0·6420 | 0·0023 | 0·5013 | 0·0312 |
| IL‐17+ IL‐6+ | 0·4909 | 0·0280 | 0·4707 | 0·0362 |
| IL‐17+ IL‐10+ | −0·1147 | 0·6303 | −0·1111 | 0·6411 |
| % TLR‐9+ CD4+ T‐cells | ||||
| IL‐17+ IFN‐γ + | 0·5565 | 0·0018 | 0·5136 | 0·0396 |
| IL‐17+ IL‐6+ | 0·6359 | 0·0026 | 0·4511 | 0·0471 |
| IL‐17+ IL‐10+ | −0·3699 | 0·1085 | −0·3193 | 0·1699 |
| % TLR‐2+ CD8+ T‐cells | ||||
| IL‐17+ IFN‐γ + | 0·7478 | 0·0002 | 0·5014 | 0·0251 |
| IL‐17+ IL‐6+ | 0·4739 | 0·0348 | 0·4509 | 0·0460 |
| IL‐17+ IL‐10+ | 0·30 | 0·7974 | 0·3098 | 0·1837 |
| % TLR‐4+ CD8+ T‐cells | ||||
| IL‐17+ IFN‐γ + | 0·6137 | 0·0040 | 0·4924 | 0·0274 |
| IL‐17+ IL‐6+ | 0·5435 | 0·0133 | 0·4115 | 0·0373 |
| IL‐17+ IL‐10+ | 0·1234 | 0·6043 | 0·1346 | 0·6043 |
| % TLR‐9+ CD8+ T‐cells | ||||
| IL‐17+ IFN‐γ + | 0·5649 | 0·0151 | 0·437 | 0·0412 |
| IL‐17+ IL‐6+ | 0·5449 | 0·0130 | 0·478 | 0·0406 |
| IL‐17+ IL‐10+ | 0·3301 | 0·1552 | 0·3057 | 0·190 |
The proportion of different T helper type 17 (Th17)‐like subsets from MS patients was compared with radiological activity of the disease (n = 18) and neurological disabilities (n = 30), determined by the Expanded Disability Status Scale (EDSS) score. IFN, interferon; IL, interleukin; TNF, tumour necrosis factor. Significant P values are highlighted in bold.