REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
APC anti-human CD41 antibody	Biolegend	Cat# 303710; RRID: AB_2249385
PE anti-human CD62P antibody	Biolegend	Cat# 304906; RRID: AB_314478
FITC anti-human CD63 antibody	Biolegend	Cat# 353005; RRID: AB_10933264
Biological Samples
779 blood platelet samples	This study	Table S1
Chemicals, Peptides, and Recombinant Proteins
OptiPrep Density Gradient Medium	Sigma-Aldrich	Cat# D1556
Multiplate TRAPtest	Roche	Cat# 06675883190
RNALater solution	Thermo Scientific	Cat# AM7020
Critical Commercial Assays
mirVana miRNA isolation kit	Ambion, Thermo Scientific	Cat# AM1560
SMARTer Ultra Low RNA Kit for Illumina Sequencing version 3	Clontech	Cat# 634853
Truseq Nano DNA Sample Prep Kit	Illumina	Cat# FC-121-4001
RNA picochip and reagents, Bioanalyzer 2100	Agilent	Cat# 5067-1513
DNA 7500 chip and reagents, Bioanalyzer 2100	Agilent	Cat# 5067-1506
DNA High Sensitivity chip and reagents, Bioanalyzer 2100	Agilent	Cat# 5067-4626
Deposited Data
Raw and processed RNA-seq data	This study	GEO: GSE89843
MISO reference files	(Katz et al., 2010)	https://miso.readthedocs.io/en/fastmiso/annotation.html
RBP reference table	(Ray et al., 2013)	Supplementary Data 2 in Ray et al. (2013)
Software and Algorithms
SAS statistical software module (version 13.0.0)	JMP	https://www.jmp.com/en_us/home.html
Trimmomatic (version 0.22)	(Bolger et al., 2014)	http://www.usadellab.org/cms/?page=trimmomatic
STAR (version 2.3.0)	(Dobin et al., 2013)	https://github.com/alexdobin/STAR
HTSeq (version 0.6.1)	(Anders et al., 2014)	http://www-huber.embl.de/HTSeq/doc/overview.html
Picardtools (version 1.115)	Broad Institute, USA	https://broadinstitute.github.io/picard/
Samtools (version 1.115)	(Li et al., 2009)	http://samtools.sourceforge.net
Bedtools (version 2.17.0)	(Quinlan and Hall, 2010)	http://bedtools.readthedocs.io/en/latest/
MISO (version 0.5.3)	(Katz et al., 2010)	https://miso.readthedocs.io/en/fastmiso/
MATLAB (version R2015b)	The MathWorks Inc., USA	https://nl.mathworks.com/products/matlab.html
R (version 3.3.0)	(R Core Team, 2016)	https://www.r-project.org
R-studio (version 0.99.902)	(RStudio, 2016)	https://www.rstudio.com
Bioconductor package edgeR (version 3.12.1)	(Robinson and Oshlack, 2010)	https://bioconductor.org/packages/release/bioc/html/edgeR.html
Bioconductor package EDASeq (version 2.4.1)	(Risso et al., 2011)	http://bioconductor.org/packages/release/bioc/html/EDASeq.html
Bioconductor package PPSO (version 0.9-9991)	(Tolson and Shoemaker, 2007)	https://www.rforge.net/ppso/
Bioconductor package RUVSeq (version 1.4.0)	(Risso et al., 2014)	http://bioconductor.org/packages/release/bioc/html/RUVSeq.html
R-package e1071 (version 1.6-7)	CRAN	https://cran.r-project.org/web/packages/e1071/index.html
R-package Caret (version 6.0-71)	CRAN	https://cran.r-project.org/web/packages/caret/index.html
R-package Optunity (version 1.0)	STADIUS lab	http://optunity.readthedocs.io/en/latest/
R-package pROC (version 1.8)	CRAN	https://cran.r-project.org/web/packages/pROC/index.html
R-package ROCR (version 1.0-7)	CRAN	https://cran.r-project.org/web/packages/ROCR/index.html
R-package PAGODA (version 1.99.1)	(Fan et al., 2016)	http://hms-dbmi.github.io/scde/index.html
R-package Seqinr (version 3.3-3)	CRAN	https://cran.r-project.org/web/packages/seqinr/index.html
R-package VennDiagram (version 1.6.17)	CRAN	https://cran.r-project.org/web/packages/VennDiagram/index.html