Table 1.
Demographics and metabolic characteristics of subjects included in analyses of visceral adipose tissue volume versus metabolic parameters
| Partial lipodystrophy + matched controls | Generalized lipodystrophy + matched controls | |||||
|---|---|---|---|---|---|---|
| Lipodystrophy (N = 50) | Healthy controls (N = 50) | p value | Lipodystrophy (N = 43) | Healthy controls (N = 43) | p value | |
| Sex | 48F, 2M | 47F, 3M | >0.99 | 34F, 9M | 35F, 8M | >0.99 |
| Age (years) | 34.5 (17.0, 46.5) | 33.5 (15.8, 46.0) | 0.72 | 15.0 (10.0, 18.0) | 12.0 (9.0, 20.0) | 0.4 |
| Race (n) | 40 WNH, 2 B, 1 WH, 7 O | 37 WNH, 5 B, 4 WH, 4 O | 0.3 | 22 WNH, 9 B, 9 WH, 3 O | 23 WNH, 7 B, 5 WH, 8 O | 0.3 |
| Height (cm) | 163 (157, 170) | 165 (161, 171) | 0.3 | 160 (148, 167) | 155 (137, 175) | 0.08 |
| Weight (kg) | 68.1 ± 17.5 | 70.7 ± 23.0 | 0.5 | 50.9 ± 16.3 | 51.1 ± 20.3 | 0.9 |
| BMI (kg m−2) | 25.7 ± 5.2 | 26.0 ± 6.8 | 0.78 | 20.2 ± 3.6 | 21.5 ± 5.3 | 0.19 |
| Total body fat (%) | 27.5 ± 5.6 | 35.0 ± 7.6 | <0.0001 | 14.5 ± 2.9 | 31.2 ± 8.0 | <0.0001 |
| VAT volume (cm3) | 534 (281, 810) | 277 (138, 443) | <0.0001 | 93 (57, 153) | 153 (101, 212) | 0.02 |
| Leg fat mass (g) | 4,017 (3,371, 5,281) | 10,631 (6,466, 14,081) | <0.0001 | 1,794 (1,371, 2,856) | 6,298 (3,762, 10,983) | <0.0001 |
| Glucose (mmol L−1) | 6.4 (5.0, 10.1) | 5.1 (4.8, 5.3) | <0.0001 | 10.0 ± 4.6 | 4.9 (4.6, 5.2) | <0.0001 |
| HbA1c (%) | 7.6 ± 2.0 | 5.3 ± 0.4 (N = 32) | <0.0001 | 8.7 ± 2.5 | 4.9 ± 0.3 (N = 9) | <0.0001 |
| Triglycerides (mmol L−1) | 3.6 (2.4, 6.3) | 0.8 (0.6, 1.3) | <0.0001 | 5.3 (2.9, 13.8) | 0.68 (0.49, 0.90) | <0.0001 |
| HDL‐C (mmol L−1) | 0.8 ± 0.3 (N = 45) | 1.6 ± 0.4 | <0.0001 | 0.7 ± 0.2 (N = 39) | 1.5 ± 0.3 | <0.0001 |
Data are presented as mean ± standard deviation for normally distributed variables and median (25th and 75th percentile) for non‐normally distributed variables. B, African–American; BMI, body mass index; HbA1c, haemoglobin A1c; HDL‐C, high‐density lipoprotein cholesterol; O, other; VAT, visceral adipose tissue; WH, White Hispanic; WNH, White non‐Hispanic.