Figure 2.

Changes over baseline of CD4⁺ T-cells (A) CD8⁺ T-cells (B) and CD4⁺/CD8⁺ T-cell ratio (C) during 8 years of follow-up. Baseline values (left panels) and annual changes over baseline (right panels) from ISS T-002 study entry of CD4⁺ T-cells (A), CD8⁺ T-cells (B), and CD4⁺/CD8⁺ T-cell ratio (C) in all vaccinees are shown. The number of participants tested are as follows. CD4⁺ T-cells: year 1 n = 92, year 2 n = 63, year 3 n = 43, year 4 n = 37, year 5 n = 52, year 6 n = 82, year 7 n = 58 year 8+ n = 37; CD8⁺ T-cells and CD4⁺/CD8⁺ T-cell ratio: year 1 n = 91, year 2 n = 59, year 3 n = 41, year 4 n = 35, year 5 n = 48, year 6 n = 78, year 7 n = 54, year 8+ n = 34. Data are presented as mean values with standard error. A longitudinal analysis for repeated measurements was applied. p-values assess the values at year 1–8 after immunization vs. baseline values.