. 2019 Feb 13;10:233. doi: 10.3389/fimmu.2019.00233

Table 2.

CD4⁺ T-cells vs. anti-Tat humoral immune response, vaccine treatment groups, viral load, and antiretroviral drug regimens.

CD4⁺ T-cells	Year^a	Estimate^b	95% CI^c		p-Value
ANTI-TAT HUMORAL RESPONSE
IgM⁺, IgG⁺, and IgA⁺	1	32	−32	96	0.3246
	2	101	10	192	0.0296
	3	89	−19	197	0.1078
	4	117	0	233	0.0492
	5	194	79	309	0.0009
	6	145	34	257	0.0106
	7	79	−26	183	0.1420
	8+	75	−20	169	0.1221
IgM⁺/IgG⁺ or IgG⁺/IgA⁺ or IgM⁺/IgA⁺	1	50	−15	115	0.1293
	2	53	−21	127	0.1575
	3	30	−28	88	0.3071
	4	175	42	309	0.0099
	5	179	44	313	0.0092
	6	140	41	239	0.0058
	7	95	−1	192	0.0528
	8+	69	−20	158	0.1277
IgM⁺ or IgG⁺ or IgA⁺	1	13	−34	61	0.5818
	2	55	−7	117	0.0815
	3	2	−126	130	0.9771
	4	63	−4	131	0.0661
	5	162	79	246	0.0001
	6	88	12	164	0.0241
	7	65	−62	193	0.3148
	8+	−57	−198	85	0.4311
Ab Negative	1	55	−7	117	0.0834
	2	72	−32	175	0.1745
	3	38	−35	110	0.3090
	4	118	−24	261	0.1039
	5	116	33	199	0.0062
	6	137	38	235	0.0064
	7	132	24	239	0.0162
	8+	211	91	332	0.0006
VACCINE TREATMENT GROUPS
Tat 7.5 μg, 3 ×	1	−7	−53	39	0.7597
	2	22	−33	76	0.4383
	3	10	−89	109	0.8417
	4	36	−79	152	0.5352
	5	115	15	216	0.0246
	6	93	−3	189	0.0565
	7	59	−43	161	0.2558
	8+	68	−26	162	0.1557
Tat 7.5 μg, 5 ×	1	67	−18	152	0.1240
	2	129	−12	270	0.0738
	3	46	−46	138	0.3293
	4	135	33	237	0.0096
	5	149	47	251	0.0044
	6	124	24	224	0.0154
	7	91	−30	212	0.1410
	8+	64	−54	182	0.2904
Tat 30 μg, 3 ×	1	65	17	112	0.0080
	2	69	10	128	0.0227
	3	27	−44	98	0.4547
	4	197	80	314	0.0009
	5	222	117	327	<0.0001
	6	130	42	218	0.0039
	7	128	28	228	0.0122
	8+	78	−12	168	0.0905
Tat 30 μg, 5 ×	1	26	−31	84	0.3712
	2	62	−10	135	0.0932
	3	75	−5	156	0.0663
	4	105	−16	226	0.0877
	5	165	60	270	0.0020
	6	162	54	271	0.0032
	7	93	−7	194	0.0684
	8+	89	−16	194	0.0983
VIRAL LOAD
At least 90% visits with 0 copies	1	60	−22	142	0.1517
	2	84	−5	174	0.0653
	3	46	−47	139	0.3331
	4	163	12	313	0.0343
	5	234	93	375	0.0011
	6	134	25	243	0.0162
	7	92	−5	189	0.0632
	8+	63	−21	148	0.1389
Less than 90% visits with 0 copies	1	15	−9	39	0.2142
	2	56	8	105	0.0215
	3	33	−22	89	0.2372
	4	74	32	117	0.0006
	5	92	53	131	<0.0001
	6	121	70	171	<0.0001
	7	94	30	157	0.0037
	8+	86	15	156	0.0172
ARV REGIMENS
NNRTI- or NRTI-based		84	41	126	0.0001
PI-based		97	33	161	0.0029

Year since first immunization;

Least square means;

Confidence interval.

Multivariate analysis of variance for repeated measures of longitudinal samples from 92 individuals.