Table 1.
Characteristics of US Adults With Definite/Probable Familial Hypercholesterolemia, Severe Dyslipidemia (Adjusted LDL-C ≥190 mg/dL), and Nonelevated LDL-C
| Characteristic | Definite/Probable FH (n=1 007 020)% (SE) |
Severe Dyslipidemia (LDL-C ≥190 mg/dL) (n=13 999 990) % (SE) |
General Population (N=212 438 580) % (SE) |
P Value* | P Value† |
|---|---|---|---|---|---|
| Age, y | 0.98 | 0.005 | |||
| 20–39 | 13.9 (5.3) | 14.8 (1.0) | 37.0 (0.5) | ||
| 40–59 | 49.3 (7.7) | 49.4 (1.2) | 38.6 (0.4) | ||
| ≥60 | 36.8 (7.0) | 35.8 (1.0) | 24.4 (0.4) | ||
| Female sex | 53.1 (8.0) | 49.3 (1.1) | 51.3 (0.2) | 0.63 | 0.83 |
| Race | 0.04 | 0.046 | |||
| Non-Hispanic white | 72.1 (6.6) | 73.0 (1.4) | 69.5 (1.1) | ||
| Non-Hispanic black | 18.5 (5.4) | 10.2 (0.8) | 11.2 (0.6) | ||
| Mexican American | 8.5 (3.3) | 11.4 (1.0) | 13.2 (0.9) | ||
| Other | 1.0 (1.0) | 5.4 (0.6) | 6.1 (0.3) | ||
| Education | 0.77 | 0.59 | |||
| Less than high school | 19.3 (4.8) | 22.4 (0.9) | 18.9 (0.5) | ||
| High school graduate | 30.1 (7.2) | 26.1 (1.2) | 24.2 (0.4) | ||
| Some college or more | 50.6 (7.5) | 51.5 (1.3) | 57.0 (0.7) | ||
| Insurance status | 0.64 | 0.31 | |||
| Uninsured | 9.6 (3.6) | 14.6 (1.0) | 18.9 (0.4) | ||
| Intermittently insured | 6.3 (4.5) | 5.0 (0.5) | 4.8 (0.1) | ||
| Fully insured | 84.1 (5.7) | 80.4 (1.1) | 76.3 (0.48) | ||
| Poverty (<133% poverty line) | 31.9 (6.6) | 22.9 (1.2) | 22.4 (0.6) | 0.13 | 0.10 |
| US-born | 91.8 (2.9) | 83.3 (1.1) | 83.4 (0.8) | 0.022 | 0.027 |
| Usual source of care | 0.38 | 0.05 | |||
| None | 7.3 (3.4) | 10.7 (0.8) | 17.1 (0.4) | ||
| Hospital outpatient or emergency | 13.8 (4.7) | 18.8 (1.0) | 18.6 (0.7) | ||
| Doctor’s office or clinic | 78.9 (5.4) | 70.5 (1.1) | 64.3 (0.7) | ||
| Body mass index | 0.39 | 0.04 | |||
| Normal weight (≤24.9 kg/m2) | 16.7 (5.7) | 17.4 (0.9) | 32.1 (0.4) | ||
| Overweight (25–29.9 kg/m2) | 29.8 (8.6) | 39.7 (1.3) | 33.6 (0.4) | ||
| Obese (≥30 kg/m2) | 53.5 (8.6) | 42.9 (1.2) | 34.4 (0.4) | ||
| Smoking status | 0.88 | 0.79 | |||
| Never | 47.4 (8.5) | 46.8 (1.3) | 52.7 (0.5) | ||
| Past | 27.5 (6.8) | 30.7 (1.1) | 24.5 (0.4) | ||
| Current | 25.1 (6.6) | 22.4 (1.0) | 22.8 (0.4) | ||
| Glucose tolerance | 0.018 | <0.001 | |||
| Normal | 26.0 (7.2) | 46.8 (1.2) | 62.1 (0.4) | ||
| Prediabetic | 53.3 (8.2) | 35.3 (1.2) | 27.4 (0.4) | ||
| Diabetic | 20.7 (5.8) | 17.9 (0.9) | 10.5 (0.2) | ||
| Blood pressure | <0.001 | <0.001 | |||
| Normal | 21.7 (6.5) | 22.4 (1.0) | 41.1 (0.5) | ||
| Prehypertensive | 2.6 (1.6) | 26.8 (1.2) | 27.7 (0.3) | ||
| Hypertensive | 75.7 (6.7) | 50.8 (1.2) | 31.2 (0.4) | ||
| Personal history of early ASCVD | 49.2 (8.4) | 7.8 (0.6) | 3.6 (0.1) | <0.001 | <0.001 |
| Family history of early ASCVD | 45.8 (8.6) | 16.4 (1.0) | 13.4 (0.3) | <0.001 | <0.001 |
ASCVD indicates atherosclerotic cardiovascular disease; FH, familial hypercholesterolemia; LDL-C, low-density lipoprotein cholesterol; and SE, standard error.
*
P value for comparison between adults with definite/probable FH and adults with severe dyslipidemia.
†
P value for comparison between adults with definite/probable FH and the general adult population.