Table 1.

Endocan cleavage ratio (ECR) according to patients’ characteristics

Variables	Absent	Present	Spearman ρ (95% CI)	p
Age (years)			0.18 (− 0.03–0.37)	0.08
Chronic comorbidities
COPD	0.33 [0.21–0.42]	0.23 [0.18–0.51]		0.53
Smoker	0.33 [0.21–0.45]	0.23 [0.18–0.35]		0.15
Cardiomyopathy	0.3 [0.2–0.42]	0.33 [0.2–0.45]		0.61
Chronic kidney failure	0.31 [0.21–0.44]	0.25 [0.05–0.56]		0.7
Cirrhosis	0.31 [0.2–0.45]	0.3 [0.21–0.37]		0.63
Sepsis severity on enrolment
Severe sepsis		0.29 [0.2–0.41]
Septic shock		0.31 [0.2–0.45]		0.74
Site of infection on enrolment
Soft tissues		0.3 [0.2–0.39]
Respiratory		0.33 [0.21–0.45]
Urinary		0.31 [0.22–0.53]		0.82
Digestive		0.31 [0.24–0.38]
Other		0.21 [0.07–0.49]
Biomarkers on enrolment
CRP (mg/L)			0 (−0.21–0.2)	0.96
PCT (ng/mL)			0.06 (− 0.15–0.26)	0.58
Prognostic scores on enrolment
SAPS 2			0.36 (0.17–0.53)	< 10−3
SOFA			0.21 (0–0.39)	0.04
LIPS			0.12 (−0.08–0.32)	0.22
Organ SOFA > 2 on enrolment
Pulmonary	0.3 [0.2–0.37]	0.35 [0.24–0.48]		0.19
Renal	0.28 [0.19–0.36]	0.38 [0.29–0.61]		< 10− 3
Hepatic	0.32 [0.21–0.42]	0.26 [0.14–0.53]		0.75
Circulatory	0.23 [0–0.39]	0.33 [0.23–0.45]		0.12
Neurological	0.3 [0.2–0.38]	0.33 [0.24–0.48]		0.19
Hematological	0.31 [0.2–0.4]	0.27 [0.12–0.54]		0.99
Mortality
Day 28	0.3 [0.19–0.38]	0.33 [0.23–0.48]		0.4
ICU discharge	0.3 [0.2–0.37]	0.33 [0.23–0.54]		0.24
ICU length of stay (days)			0.16 (−0.04–0.35)	0.11
Mechanical ventilation on enrolment	0.3 [0.19–0.37]	0.31 [0.23–0.47]		0.33

ECR are presented as median [IQR] values according to presence or absence of categorical variables. A Mann-Whitney test was used for comparison between two groups. A Kruskal-Wallis test was used for comparison between three or more groups. Correlations between ECR and continuous variables are described through Spearman ρ (95% CI)

COPD chronic obstructive pulmonary disease, SOFA Sequential Organ Failure Assessment, ICU intensive care unit, SAPS 2 Simplified Acute Physiology Score 2, LIPS Lung Injury Prediction Score