Table 4.

Multivariable logistic regression analyses examining the moderating effect of MTHFR 677C>T genotype ^a on the association between homocysteine and placenta-mediated complications, n = 4006

Outcome variable	Odds ratio (95% CI) for 5 μmol/L increase b		p-value c
	TT	CC/CT
Any placenta-mediated complication (395 events d)	0.712 (0.243, 2.083)	1.778 (1.159, 2.729)	0.1172
SGA (277 events d)	0.639 (0.161, 2.536)	2.430 (1.450, 4.073)	0.0714
Preeclampsia (109 events)	1.174 (0.523, 2.633)	1.258 (0.682, 2.322)	0.8439

^aHomocysteine*MTHFR 677C>T genotype (Factor + higher order factors)

^bModel adjusted for maternal age, race, education, parity, smoking, diabetes, BMI, hormonal birth control, chronic hypertension, history of PMC, folic acid supplementation, serum folate, gestational age at blood work

^cWald test of most meaningful hypotheses, pooled across multiple imputation datasets

^d40 Missing outcome values imputed