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. 2019 Feb 20;7:24. doi: 10.1186/s40478-019-0668-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Occurrence of histone H3.3 K27M- (upper panel) and H3.3 G34-mutant gliomas in our cohort and the association with ATRX protein loss. Rarely, a biphasic pattern of ATRX expression is observed both in H3 K27M- and H3 G34R-mutant gliomas (light purple boxes). On one occasion we have identified H3F3A G34V mutation (asterisk in the age group 16–20 years). In another recurrent high-grade glioma, both primary and recurrent tumours were classified as H3 G34-mutant glioblastoma, although no mutations could be found in H3F3A, HIST1H3B and HIST1H3C genes (asterisk in the age group 36–40)