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. 2019 Feb 20;7:24. doi: 10.1186/s40478-019-0668-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — a, the outcome of methylation profiling of 44 IDH-wildtype CNS tumours with low-grade histology. Of these, 26 resolved into methylation classes associated with low-grade behaviour, and 18 resolved into entities associated with high-grade behaviour. b, shows how various tumours manifesting with low-grade histology resolve into distinct high-grade methylation classes. Abbreviations in a: LGG, GG: Low-grade glioma, ganglioglioma; LGG, SEGA: Low-grade glioma, subependymal giant cell astrocytoma; LGG, RGNT: Low-grade glioma, rosette forming glioneuronal tumour; LGG, DNT: Low-grade glioma, dysembryoplastic neuroepithelial tumour; LGG, MYB: Low-grade glioma with MYB alteration; LGG, PA PF: Low-grade glioma, pilocytic astrocytoma in posterior fossa; LGG, PA/GG ST: Low-grade glioma, pilocytic astrocytoma ganglioglioma spectrum in supratentorial compartment; A PA: Anaplastic pilocytic astrocytoma (anaplastic astrocytoma with piloid features); A IDH, HG: IDH-mutant high-grade astrocytoma; GBM, G34: H3 G34-mutant glioblastoma; DMG, K27: H3 K27-mutant diffuse midline glioma; GBM, RTK II: IDH-wildtype glioblastoma, RTK II subclass; GBM, MES: IDH-wildtype glioblastoma, mesenchymal subclass. Abbreviations in b: Glioma NOS IDHmt: IDH-mutant glioma, not otherwise specified; LGG-Glioneuronal: Low-grade glioma or glioneuronal tumour; LGG NOS IDHwt: IDH-wildtype low-grade glioma not otherwise specified; PA: Pilocytic astrocytoma; Neurocytoma, IDHwt: IDH-wildtype neurocytoma; PXA: pleomorphic xanthoastrocytoma; A IDH, HG: IDH-mutant high-grade astrocytoma; ANA PA: Anaplastic pilocytic astrocytoma (anaplastic astrocytoma with piloid features); DMG, K27: H3 K27-mutant diffuse midline glioma; GBM, G34: H3 G34-mutant glioblastoma; GBM, MES: IDH-wildtype glioblastoma, mesenchymal subclass; GBM, RTK II: IDH-wildtype glioblastoma, RTK II subclass