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. 2019 Feb 20;14:59. doi: 10.1186/s13018-019-1091-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — The effect of specific siRNAs on regulation of matrix-degrading enzyme gene transcription in SW1353 cells. SW1353 cells were treated with scrambled siRNA or specific siRNA targeting BRD2, BRD3, and BRD4 for 48 h and then treated with or without IL-1β (10 ng/ml) or TNF-α (10 ng/ml) for 6 h. a–d The transcriptional expression of MMP1, MMP3, MMP13, and ADAMTS4 was evaluated by real time-PCR. Relative fold-change values were calculated in comparison with the vehicle control that was set to 1 (n = 3)