Fig. 4.

Time-course of significantly regulated p-sites in the context of cell process important for short-term regulation of glucose-induced insulin secretion. Panels includes phospho-regulated proteins in the context of, exocytosis (a), calcium and ion homeostasis (b), vesicle trafficking and biogenesis (c), cytoskeleton organization (d), protein translation (e) and metabolism (f). Fast glucose-regulated p-sites are colored in green, late regulated p-sites are colored in blue and p-sites displaying an intermediate regulatory-kinetic are colored in red. g P-site kinetics of proteins involved in the above mentioned cell process. P-sites included undergoes more than FC (Log2) > 0.3 or < − 0.3 regulation during at least some of the three time points studied (5, 30 and 60 min) and p-value ≤0.05