Fig. 4.

Flowchart of the IDHI-MIRW. a building three lncRNA similarity networks and three disease similarity networks by calculating the Pearson correlation coefficient and Gaussian interaction profile kernel similarity. b forming the lncRNA/disease topological similarity networks with RWR and positive pointwise mutual information. c constructing the large-scale lncRNA-disease heterogeneous network by integrating lncRNA/disease topological similarities and known lncRNA-disease associations. d predicting the potential lncRNA-disease associations by implementing RWRH