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. 2019 Feb 20;11:33. doi: 10.1186/s13148-019-0626-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Differentially methylated CpG sites from 450K array (Illumina) between the responder and non-responder group. a Workflow summary. b Hierarchical clustering heatmap of differentially methylated CpGs: 133 CpGs (71 genes) differentially methylated were found between responders (R) and non-responders (NR) group identified from 450K array analysis with mean differences in methylation levels ≥ 20% (p < 0.05). c Most representative biological processes of the 71 differentially methylated genes according to Gene Ontology analysis