Table 2.

List of drug-tissue associations conserved across in vitro and clinical settings

Tissue	Drug	In vitro FDR	In vitro efficacy	In vitro predictability	DrugBank
Non–small-cell lung cancer	Erlotinib	0.011	0.18	0.60	DB00530
Breast	Lapatinib	0.009	0.62	0.58	DB01259
Soft tissue	Etoposide	0.006	0.43	0.64	DB00773
Skin	Etoposide	1.3e-8	0.91	0.71	DB00773
Large intestine	Imatinib	0.0002	0.56	0.67	DB00619

In vitro FDR: false discovery rate computed from the x for all drug-tissue associations investigated in our study; In vitro efficacy: upper quartile of the AUC distribution for the drug of interest in the associated tissue type (≤0.2 indicative of lack of in vitro efficacy); In vitro predictability: concordance index of the binary value representing the tissue in the association, testing how well the associated tissue can predict drug sensitivity; DrugBank: link to the DrugBank database for the drug of interest.