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. Author manuscript; available in PMC: 2019 Feb 20.
Published in final edited form as: Kidney Int. 2017 Oct 13;93(2):501–509. doi: 10.1016/j.kint.2017.07.025

Table 3 |.

Myocardial perfusion PET results, according to CKD stage

Imaging parameter Preserved kidney
function (n = 198)
Stage 1 CKD
(n = 602)
Stage 2 CKD
(n = 1292)
Stage 3 CKD
(n = 901)
Stage 4 CKD
(n = 216)
Stage 5 CKD
(n = 112)
Dialysis
(n = 175)
P valuea
Peak myocardial blood flow, ml/min/g 2.27 ± 1.07b 2.17 ± 0.99b,c 1.97 ± 0.91b,c 1.69 ± 0.77c 1.50 ± 0.72c 1.70 ± 0.73c 1.82 ± 0.82c <0.001
Resting blood flow, ml/min/g 1.17 ± 0.53b 1.09 ± 0.44 1.07 ± 0.47 1.03 ± 0.40c 1.05 ± 0.38 1.17 ± 0.45b 1.20 ± 0.47b <0.001
CFR 2.01 ± 0.67b 2.06 ± 0.74b 1.91 ± 0.72b 1.68 ± 0.59c 1.47 ± 0.62b,c 1.47 ± 0.42b,c 1.55 ± 0.54c <0.001
Corrected CFR 2.10 ± 0.91b 2.06 ± 0.85b 1.92 ± 0.85b 1.71 ± 0.69c 1.54 ± 0.77c 1.66 ± 0.50c 1.89 ± 2.13 <0.001
CVR, mm Hg/ml/min/g 99.91 ± 52.11 102.35 ± 43.65 105.06 ± 44.44 105.67 ± 42.31 108.78 ± 98.49 99.29 ± 36.08 95.59 ± 44.89 0.07
Agatston score, median 0.0 (0.0, 6.0) 1.0 (0.0, 125.0) 58.0, (0.0, 389.0) 249.5 (20.0, 984.0) 274.0 (35.0, 1134.0) 165.0 (0.0, 707.0) 96.0 (0.0, 999.0) <0.001
Ejection fraction, % 59.98 ± 10.46b 58.93 ± 12.58b 56.01 ± 13.91b,c 52.63 ± 15.70c 47.35 ± 14.74b,c 50.82 ± 12.62c 50.35 ± 14.27c <0.001
LV mass, g 137.77 ± 26.89 136.70 ± 33.61 137.64 ± 37.74 142.63 ± 41.48 159.85 ± 44.97b,c 161.28 ± 44.10b,c 158.37 ± 39.50b,c <0.001
Ischemic percentage, % 2.20 ± 5.88b 3.65 ± 7.18b 4.07 ± 7.24b,c 5.43 ± 8.42c 5.59 ± 8.13c 4.70 ± 6.85 4.35 ± 8.22 <0.001
Summed difference score 1.50 ± 4.00b 2.48 ± 4.88b 2.77 ± 4.92b,c 3.69 ± 5.73c 3.80 ± 5.53c 3.20 ± 4.66 2.96 ± 5.59 <0.001
Summed rest score 1.14 ± 3.46b 1.69 ± 4.59b 2.82 ± 6.36b,c 3.67 ± 7.05c 5.25 ± 8.03b,c 2.40 ± 6.39 2.30 ± 5.05 <0.001
Summed stress score 2.64 ± 6.06b 4.17 ± 7.42b 5.59 ± 8.69b,c 7.37 ± 9.68c 9.05 ± 10.39c 5.60 ± 8.58 5.26 ± 8.51 <0.001

CFR, coronary flow reserve; CKD, chronic kidney disease; CVR, coronary vascular resistance; LV, left ventricular; min, minute; PET, positron emission tomography.

a

Categorical P value using analysis of variance. Tests for trends were performed using Cuzick nonparametric test for trend.

b

P < 0.05 versus stage 3 CKD.

c

P < 0.05 versus preserved kidney function.