Table 3 |.
Imaging parameter | Preserved kidney function (n = 198) |
Stage 1 CKD (n = 602) |
Stage 2 CKD (n = 1292) |
Stage 3 CKD (n = 901) |
Stage 4 CKD (n = 216) |
Stage 5 CKD (n = 112) |
Dialysis (n = 175) |
P valuea |
---|---|---|---|---|---|---|---|---|
Peak myocardial blood flow, ml/min/g | 2.27 ± 1.07b | 2.17 ± 0.99b,c | 1.97 ± 0.91b,c | 1.69 ± 0.77c | 1.50 ± 0.72c | 1.70 ± 0.73c | 1.82 ± 0.82c | <0.001 |
Resting blood flow, ml/min/g | 1.17 ± 0.53b | 1.09 ± 0.44 | 1.07 ± 0.47 | 1.03 ± 0.40c | 1.05 ± 0.38 | 1.17 ± 0.45b | 1.20 ± 0.47b | <0.001 |
CFR | 2.01 ± 0.67b | 2.06 ± 0.74b | 1.91 ± 0.72b | 1.68 ± 0.59c | 1.47 ± 0.62b,c | 1.47 ± 0.42b,c | 1.55 ± 0.54c | <0.001 |
Corrected CFR | 2.10 ± 0.91b | 2.06 ± 0.85b | 1.92 ± 0.85b | 1.71 ± 0.69c | 1.54 ± 0.77c | 1.66 ± 0.50c | 1.89 ± 2.13 | <0.001 |
CVR, mm Hg/ml/min/g | 99.91 ± 52.11 | 102.35 ± 43.65 | 105.06 ± 44.44 | 105.67 ± 42.31 | 108.78 ± 98.49 | 99.29 ± 36.08 | 95.59 ± 44.89 | 0.07 |
Agatston score, median | 0.0 (0.0, 6.0) | 1.0 (0.0, 125.0) | 58.0, (0.0, 389.0) | 249.5 (20.0, 984.0) | 274.0 (35.0, 1134.0) | 165.0 (0.0, 707.0) | 96.0 (0.0, 999.0) | <0.001 |
Ejection fraction, % | 59.98 ± 10.46b | 58.93 ± 12.58b | 56.01 ± 13.91b,c | 52.63 ± 15.70c | 47.35 ± 14.74b,c | 50.82 ± 12.62c | 50.35 ± 14.27c | <0.001 |
LV mass, g | 137.77 ± 26.89 | 136.70 ± 33.61 | 137.64 ± 37.74 | 142.63 ± 41.48 | 159.85 ± 44.97b,c | 161.28 ± 44.10b,c | 158.37 ± 39.50b,c | <0.001 |
Ischemic percentage, % | 2.20 ± 5.88b | 3.65 ± 7.18b | 4.07 ± 7.24b,c | 5.43 ± 8.42c | 5.59 ± 8.13c | 4.70 ± 6.85 | 4.35 ± 8.22 | <0.001 |
Summed difference score | 1.50 ± 4.00b | 2.48 ± 4.88b | 2.77 ± 4.92b,c | 3.69 ± 5.73c | 3.80 ± 5.53c | 3.20 ± 4.66 | 2.96 ± 5.59 | <0.001 |
Summed rest score | 1.14 ± 3.46b | 1.69 ± 4.59b | 2.82 ± 6.36b,c | 3.67 ± 7.05c | 5.25 ± 8.03b,c | 2.40 ± 6.39 | 2.30 ± 5.05 | <0.001 |
Summed stress score | 2.64 ± 6.06b | 4.17 ± 7.42b | 5.59 ± 8.69b,c | 7.37 ± 9.68c | 9.05 ± 10.39c | 5.60 ± 8.58 | 5.26 ± 8.51 | <0.001 |
CFR, coronary flow reserve; CKD, chronic kidney disease; CVR, coronary vascular resistance; LV, left ventricular; min, minute; PET, positron emission tomography.
Categorical P value using analysis of variance. Tests for trends were performed using Cuzick nonparametric test for trend.
P < 0.05 versus stage 3 CKD.
P < 0.05 versus preserved kidney function.