Table 2.

Angiographic findings in symptomatic and asymptomatic patients with a history of mediastinal malignancies treated with high-dose radiation exposure

						Coronary angiography (% of cases with the specified disease severity)
Study, design		N	Mean study interval, years	Mean/ median age, years^*	Radiation exposure, Gy (mean)	≥70% of LAD, LCx, or RCA:			Ostial vessel ≥50%	LM≥50%	LM≥70%
Study, design		N	Mean study interval, years	Mean/ median age, years^*	Radiation exposure, Gy (mean)	1- v	2- v	3- v	Ostial vessel ≥50%	LM≥50%	LM≥70%
Orzan et al, 1993¹⁰ retrospective, observational	Symptomatic	24 HL/BCA survivors 15 for CAG	12	44	>45^†	40	20	13	67%	47%	43%
McEniery et al, 1987⁹ retrospective, case–control		15 HL/BCA survivors 15 for CAG	16	48	41	53	20	7	27%	33%	20%
Correa et al, 2007⁴⁶ retrospective, case–control		46 BCA survivors 13 for CAG	15	55	60–65^†	31	23	0	NA	NA	NA
Heidenreich et al, 2007¹³ prospective, observational	Asymptomatic	294 HL survivors 40 for CAG	6.5	42	44	10	10	NA^‡	>28%	NA	50%^‡
Rademaker et al, 2008⁴⁷ retrospective, case series		9 HL survivors 9 for CCTA	26	45	40	33	0	0	0	9%	9%
Daniels et al, 2014⁴⁸ prospective, observational		48 HL survivors for CCTA 8 for CAG	21	47	36	33	0	0	33%	0	22%

Denotes age at time of angiography.

^†

Reported as ‘chest’ or ‘mediastinal dose’; elsewhere, mean heart doses are reported.

^‡

Reported as left main≥70% or three-vessel disease with at least one vessel with ≥70% stenosis.

BCA, breast cancer; CAG, coronary angiography; CCTA, coronary CT angiography; LAD, left anterior descending; LCx, left circumflex coronary artery; LM, left main; NA, not available; RCA, right coronary artery.