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. Author manuscript; available in PMC: 2019 Feb 20.
Published in final edited form as: Curr Opin Biotechnol. 2018 Oct 13;55:151–158. doi: 10.1016/j.copbio.2018.09.006

Figure 4.

Figure 4

SERS-based methods for detection of epigenetic marks. (a) Nanoparticles functionalized with DNA and dye molecules allow to determine the degree of methylation. Adapted from Ref. [49] with permission from The Royal Society of Chemistry. (b) Direct label-free detection of various DNA modifications by silver nanoparticles that aggregate in the presence of DNA, leading to a shift of their surface plasmon resonance and consequently a color change of the nanoparticle solution. Two SERS bands show an intensity change for the modified nucleobases 5mC and 5hmC [53].