Table 1. The ranked list of predictors by importance for 5-year outcomes.
| Rank | Predictor | Recurrence | Overall survival | ||
|---|---|---|---|---|---|
| χ2 | p-value | χ2 | p-value | ||
| 1 | pathologic stage subgroup (OC, EV, N+) ** | 364.0 | 0.000 | 600.0 | 0.000 |
| 2 | pT stage TNM 5th Edition ** | 307.3 | 0.000 | 584.0 | 0.000 |
| 3 | pT stage TNM 7th Edition ** | 301.8 | 0.000 | 584.0 | 0.000 |
| 4 | pN stage TNM 7th Edition ** | 291.3 | 0.000 | 410.0 | 0.000 |
| 5 | pM stage TNM 7th Edition ** | 288.7 | 0.000 | 412.0 | 0.000 |
| 6 | pN stage TNM 5th Edition ** | 292.0 | 0.000 | 402.0 | 0.000 |
| 7 | # of positive lymph nodes ** | 294.1 | 0.000 | 349.0 | 0.000 |
| 8 | pathologic positive lymph nodes ** | 267.0 | 0.000 | 393.0 | 0.000 |
| 9 | pathologic lymphovascular invasion ** | 172.1 | 0.000 | 264.0 | 0.000 |
| 10 | clinical T stage (preoperative) * | 99.6 | 0.000 | 176.0 | 0.000 |
| 11 | type of urinary diversion constructed ** | 43.4 | 0.000 | 169.0 | 0.000 |
| 12 | neoadjuvant chemotherapy subgroups * | 102.2 | 0.000 | 78.4 | 0.000 |
| 13 | age at time of cystectomy (discretized) ** | 11.7 | 0.232 | 174.0 | 0.000 |
| 14 | positive soft tissue surgical margin ** | 14.5 | 0.000 | 160.0 | 0.000 |
| 15 | urinary diversion subgoups ** | 22.8 | 0.000 | 156.0 | 0.000 |
| 16 | # of neoadjuvant chemo cycles * | 91.6 | 0.000 | 58.6 | 0.000 |
| 17 | type of surgical procedure ** | 44.0 | 0.000 | 134.0 | 0.000 |
| 18 | clincial staging subgroup (preoperative) * | 60.2 | 0.000 | 110.0 | 0.000 |
| 19 | pathologic predominant cell type ** | 65.6 | 0.000 | 86.3 | 0.000 |
| 20 | type of neoadjuvant chemotherapy * | 72.8 | 0.000 | 63.7 | 0.000 |
| 21 | adjuvant chemotherapy subgroups *** | 76.3 | 0.000 | 33.8 | 0.000 |
| 22 | type of adjuvant chemotherapy *** | 67.6 | 0.000 | 54.7 | 0.000 |
| 23 | pathologic carcinoma in situ ** | 66.9 | 0.000 | 47.1 | 0.000 |
| 24 | pM stage TNM 5th Edition ** | 1.8 | 0.399 | 111.0 | 0.000 |
| 25 | pathologic multifocal tumors ** | 62.1 | 0.000 | 29.2 | 0.000 |
| 26 | clinical N Stage (preoperative) * | 45.7 | 0.000 | 69.9 | 0.000 |
| 27 | # lymph nodes removed ** | 19.7 | 0.006 | 74.7 | 0.000 |
| 28 | intracorporeal diversion performed ** | 39.1 | 0.000 | 40.0 | 0.000 |
| 29 | # of adjuvant chemo cycles *** | 40.0 | 0.000 | 6.1 | 0.413 |
| 30 | pathologic tumor grade ** | 35.2 | 0.000 | 22.5 | 0.000 |
Association between predictors and the two long term outcomes, recurrence and OS as measured by the chi-squared test of independence. Predictors are ranked by Eq 1. Predictors are measured at three time points:
* before cystectomy,
** at time of cystectomy,
*** post-cystectomy.