Table 4. DAVID functional annotation results of LES vs LPE comparison.

Only significant functional terms (P ≤ 0.05) are reported with the relative list of annotated genes found in this comparison.

Category	Up-regulated DEGs in LES compared to LPE	P-value
KEGG Pathway (9 DEGs found*)
cGMP-PKG signaling pathway	ATP1B1, ROCK2, PLN, ATP1A2	0.0236
cAMP signaling pathway	ATP1B1, ROCK2, PLN, ATP1A2	0.0228
GO Biological Process (17 DEGs found*)
GO:1903779 regulation of cardiac conduction	TRDN, ATP1B1, PLN, ATP1A2	0.0041
GO:0055119 relaxation of cardiac muscle	ATP1B1, PLN, ATP1A2	0.0060
Category	Down-regulated DEGs in LES compared to LPE	P-value
GO Biological Process (57 DEGs found*)
GO:0006457 protein folding	HSP90AB1, HSP90AA1, CRYAB, FKBP4, BAG3, SACS, DNAJA4, HSPA8	0.0014
GO:1900034 regulation of cellular response to heat	HSP90AB1, HSP90AA1, CRYAB, FKBP4, BAG3, HSPA8	0.0016

* = Number of DEGs found associated with each category (GO Biological Process or Pathway).