Table 2A.
Patients characteristics associated with cNL in univariable GEE analysis.
| OR (95% CI) | P value | |
|---|---|---|
| Maternal characteristics | ||
| Age at delivery | 1.0 (0.9-1.1) | 0.39 |
| Primary or secondary SS | 1.9 (1.2-2.9) | < 0.01 |
| Anti-La antibody positive | 3.0 (1.8-4.7) | < 0.01 |
| Hydroxychloroquine | 0.4 (0.2-0.6) | < 0.01 |
| Fluorinated steroids±IVIG±plasmapheresis | 1.4 (0.6-3.5) | 0.47 |
| Non-fluorinated steroids±azathioprine | 0.5 (0.3-0.7) | < 0.01 |
| Children characteristics | ||
| Female gender | 1.5 (1.0-2.3) | 0.04 |
| Born ≥year 2000 | 1.1 (0.7-1.8) | 0.54 |
| Sibling with cNL and/or cardiac NL | 1.5 (0.9-2.4) | 0.10 |
| Registrya | 2.1 (1.4-3.3) | < 0.01 |
cNL, cutaneous neonatal lupus; GEE, generalized estimating equations; IVIG, intravenous immunoglobulin; NL, neonatal lupus; OR (95% CI), odds ratio (95% confidence interval); RRNL, Research Registry for Neonatal Lupus; SS, Sjogren's syndrome.
a
Comparator is the SickKids NLE Database Registry.