. Author manuscript; available in PMC: 2019 Feb 20.

Published in final edited form as: Curr Opin Endocrinol Diabetes Obes. 2018 Feb;25(1):61–66. doi: 10.1097/MED.0000000000000382

Table 1.

Comparison of Studies evaluating Bone Formation and Resorption in DS

Study	DS Group	Control Group	Marker of bone formation	Marker of bone resorption	Marker of bone turnover	Bone formation Conclusions:	Bone resorption Conclusions:
Sakadamis 2002¹²	11 adult men with DS (average age of 26.5)	12 controls	none	none	OHP:Cr	none	Bone turnover increased in DS
McKelvey 2012¹³	30 adults (men and women) with DS (age 19–52)	8 controls	P1NP	CTx	none	Decreased in DS	Similar in controls
Fowler 2012¹¹	Ts65Dn Mouse	Littermates without Ts65Dn triploidy	P1NP	TRAP 5b	none	Decreased in DS	Decreased in DS
Garcia-Hoyos 2017⁵	75 adults over 18 years (men and women)	76 controls	P1NP	CTx	none	Increased in DS	Similar to controls

P1NP: N-terminal propeptide of type 1 collagen

CTx: C-terminal telopeptide of type 1 collagen

OHP:Cr = hydroxyproline to creatinine ratio