Figure 3. Histological analysis of maxillae from rats with periodontal disease. (A) Normal periodontium (no ligature group) showing alveolar bone integrity, absence of or only discrete cellular infiltration, and preserved alveolar bone. (B) Periodontium from a rat with periodontitis (ligature group) showing alveolar bone and cementum resorption (discontinuous cementum) and accentuated inflammatory cell infiltration. (C) Periodontium from a rat with periodontitis treated with 1 mg/kg gliclazide (GLI) showing reduced inflammation and decreased alveolar bone loss. (D) Periodontium from a rat treated with 5 mg/kg gliclazide showing moderate cellular infiltration. (E) Periodontium from a rat treated with 10 mg/kg gliclazide showing no reduced inflammation and increased experimental PD. PL, periodontal ligament; D, dentin; AB, alveolar bone; C, cementum; a, inflammatory process; b, bone loss; c, resorption of cementum; d decreased inflammation process. Sections were stained with hematoxylin and eosin. Original magnification, 40×. Histopathological scores. *p<0.05, **p<0.01, ***p<0.001.