Table 4. Comparison of biomarker concentrations (pg/ml) in the individuals in the GTP groups with healthy implants diagnosed at final exam(T2).

	MP(T1)	Healthy(T2)	PI (T2)
		Mean (SD)	Mean (SD)	p*
IL-1	20137.28 (26300.93)	13655.44 (24495.43)	102081.93 (217171.72)	0.179
IL-10	4.38 (9.04)	1.87 (6.47)	4.88 (9.56)	0.523
TNF-α	-	-	2.23 (5.91)	-
TGF-β	10.90 (13.04)	8.82 (8.45)	23.78 (36.70)	0.998
MMP-2	7.98 (5.03)	6.16 (2.24)	7.34 (5.09)	0.704
RANK	2.05 (5.05)	1.25 (4.35)	-	0.532
OPG	8.24 (9.68)	10.82 (12.37)	6.48 (4.21)	0.860

GNTP: group without periodontal/peri-implant maintenance; GTP: group with periodontal/peri-implant maintenance. IL: Interleukin; TNF: tumor necrosis factor; TGF: transforming growth factor; MMP: metalloproteinase; RANK: Receptor activator of nuclear factor kappa; OPG: Osteoprotegerin; T1: initial examination; T2: final exam; n: individuals; MP: peri-implant mucositis; PI: peri-implantitis; SD standard deviation