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. 2019 Feb 20;14(2):e0212309. doi: 10.1371/journal.pone.0212309

Table 3. Causes of Ki-67 LI discrepancies between visual assessment and automated digital image analysis.

Cause of discrepancy n (%)
Tumor heterogeneity 98 (56.0%)
Visual assessment interpretation error 32 (18.3%)
Misidentification of tumor cells 26 (14.9%)
Poor immunostaining or slide quality 16 (9.1%)
Non-tumor cells estimated 3 (1.7%)