Figure 3.

Distinct Requirements for IKK1 and IKK2 Expression for Thymocyte Survival and Peripheral T Cell Homeostasis

(A) Total numbers of thymocyte subsets from mice with combinations of Chuk and Ikbkb gene deletions indicated in the axis label (+ indicates WT allele, − indicates floxed allele, all mice cre+). Numbers of mice (n) analyzed per group are indicated in the x axis.

(B) Charts show IL-7R MFI (mean fluorescence intensity) of the indicated genotype by CD4⁺ and CD8⁺ naive T cells.

(C) Total numbers of CD4⁺ (left) and CD8⁺ (right) naive T cells recovered from combined lymph node and spleen of mice with the indicated combinations of Chuk and Ikbkb deletion.

Data are the pool of eight independent experiments with 3–18 mice per genotype. Error bars indicate SD. Significant differences versus WT are indicated.