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. 2019 Feb 17;25:129–142.

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Copyright © 2019 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.

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Histopathology of whole globes with low magnification in Yap1^+/- and WT mice. Histopathology demonstrating globe size from a WT mouse with normal eyes (A) versus Yap1^+/− mice with microphthalmia and anterior segment dysgenesis (B). Eyes from the Yap1^+/− mice also demonstrated microphakia with cataractous changes characterized by marked degeneration and liquefaction of lens fibers, formation of Morgagnian globules, as well as bladder cells (D) versus age-matched WT mice with an appropriate lens size and morphology (C). (A and B) 2X, 1 year old; (C and D) 20X, 2 months old.