Table 1.

Effect size of patient clinical change and family burden, and linear mixed bivariate analysis of changes in family burden, 2001–2004 Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE).

	Cohen’s d effect size of patient clinical change	Change in factor 1		Change in factor 2		Change in factor 3		Change in factor 4
		B	P- Value	B	P- value	B	P- value	B	P- value
Model 1:
Change in PANSS (total)	−0.39	−0.04	0.287	0.01	0.814	−0.05	0.133	0.03	0.377
Model 2:
Change in QOL (Heinrichs-Carpenter)	0.14	0.05	0.209	0.07	0.099	−0.00	0.903	−0.06	0.156
Model 3:
Change in QOL (Lehman)	0.11	0.08	0.027	0.07	0.072	−0.03	0.465	−0.06	0.134
Model 4:
Change in Depression (Calgary)	−0.15	−0.01	0.792	0.06	0.105	0.02	0.531	0.03	0.341
Model 5:
Change in SF-12 mental health summary	0.14	−0.07	0.081	−0.02	0.736	0.01	0.717	−0.01	0.775
Model 6:
Time		−0.02	<0.001	−0.02	<0.001	−0.01	0.034	0.01	0.242
Model 7:
Living with the patient		0.12	0.074	0.39	<0.001	0.14	0.049	0.66	<0.001
Cohen’s d effect size of family burden change		−0.28	-	−0.26	-	−0.08	-	−0.02	-

Note: Factor 1 denotes caregiver perceived patient problem behavior, factor 2 denotes resource demands and routine disruption for the caregiver, factor 3 denotes impairments in caregiver activities of daily living, and factor 4 denotes perceived patient helpfulness to the caregiver. B stands for a standardized coefficient from a standardized linear mixed bivariate analysis.