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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Trends Endocrinol Metab. 2019 Jan 7;30(3):177–188. doi: 10.1016/j.tem.2018.12.002

Figure 1. SIRT1 is a multifaceted regulator in the pluripotent ESCs.

Figure 1.

SIRT1 is critically involved in the maintenance of pluripotent ESCs and animal development through multi-level mechanisms. The expression of SIRT1 in ESCs is under transcriptional control of Oct4, and the interaction between SIRT1, Oct4, and Myc are important to metabolically and epigenetically maintain pluripotent ESCs. SIRT1 also actively represses the expression of developmental and differentiation genes through deacetylation of histones and inhibition of cellular RA signaling. Finally, SIRT1 enhances stress response of ESCs by repressing p53 and promoting DNA repair.