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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Trends Endocrinol Metab. 2019 Jan 7;30(3):177–188. doi: 10.1016/j.tem.2018.12.002

Figure 3. Sirtuins are crucial regulators of HSC functions in response to stress and aging.

Figure 3.

Three nuclear sirtuins, SIRT1, SIRT6, and SIRT7 are actively involved in controlling HSC quiescence, which is important to maintain their regenerative capacity and prevent premature aging. Mitochondrial SIRT3 is critical to protect HSCs from age-induced oxidative stress and is therefore indispensable for HSC self-renewal.