Table 3.
Association between Total PCB concentration sum1 (dichotomized using a median split) and ASD and Non-TD
| ASD vs. TD | Non-TD vs. TD | ||||||
|---|---|---|---|---|---|---|---|
| Exposure | TD (n = 60) | ASD (n = 21) | Non-TD (n = 23) | OR (95% CI) | P-Value | OR (95% CI) | P-Value |
| Frequency (%) | |||||||
| Total PCB Lipid-Standardized Crude Model | |||||||
| M1 (33.63 – 117.97 ng/g of lipid) | 33 (55) | 9 (43) | 10(43) | Reference | Reference | ||
| M2 (119.35 – 662.34 ng/g of lipid) | 27 (45) | 12 (57) | 13 (57) | 1.63 (0.60 to 4.44) | 0.34 | 1.59 (0.60 to 4.19) | 0.35 |
| Total PCB Lipid-Standardized Adjusted Model2,3 | |||||||
| M1 (33.63 – 117.97 ng/g of lipid) | 33 (56) | 9 (43) | 8 (38) | Reference | Reference | ||
| M2 (119.35 – 662.34 ng/g of lipid) | 26 (44) | 12 (57) | 13 (62) | 1.50 (0.53 to 4.23) | 0.44 | 1.87 (0.65 to 5.37) | 0.25 |
PCB = Polychlorinated Biphenyl, TD = Typical Development, ASD = Autism Spectrum Disorder, Non-TD = Non-Typical Development, M1 = Lowest 50% PCB concentration, M2 = Highest 50% PCB concentration
1
Sum included concentration from: PCB 11, PCB 52, PCB 77, PCB 84, PCB 91, PCB 95, PCB 101, PCB 118, PCB 132, PCB 136, PCB 138, PCB 153, PCB 174, PCB 175, PCB 176, PCB 180 and PCB 196 collected during the 3rd trimester of pregnancy,
2
Loss of 3 observations due to missing prenatal vitamin use,
3
Adjusted for maternal education and prenatal vitamin use in month 1 of pregnancy