Table 3.
Reproductive outcomes in third generation women, according to their mother’s prenatal DES exposure status.
| Baseline | Follow-up | |||||
|---|---|---|---|---|---|---|
| Mother’s prenatal DES exposure status | Mother’s prenatal DES exposure status | |||||
| Outcome | Exposed (n =796) No. (%) |
Unexposed (n = 469) No. (%) |
PRa (95% CI) | Exposed (n = 381) No. (%) |
Unexposed (n = 280) No. (%) |
RRb (95% CI) |
| Ever been pregnant | ||||||
| No | 588 (74.0) | 304 (64.8) | 144 (44.2) | 87 (38.7) | ||
| Yes | 207 (26.0) | 165 (35.2) | 0.91 (0.86,0.97) | 182 (55.8) | 138 (61.3) | 0.99 (0.92,1.06) |
| Ever had a live birthc | ||||||
| No | 64 (31.2) | 48 (29.3) | 18 (9.9) | 22 (15.9) | ||
| Yes | 141 (68.8) | 116 (70.7) | 1.04 (0.87,1.25) | 164 (90.1) | 116 (84.1) | 1.08 (1.00, 1.16) |
| Ever have an adverse pregnancy outcomed | ||||||
| No | 142 (68.6) | 118 (71.5) | 129 (70.9) | 98 (71.0) | ||
| Yes | 65 (31.4) | 47 (28.5) | 1.12 (0.87,1.44) | 53 (29.1) | 40 (29.0) | 1.01 (0.72,1.41) |
| Miscarriaged | 48 (23.2) | 36 (21.8) | 1.06 (0.75,1.50) | 31 (17.0) | 29 (21.0) | 0.80 (0.40,1.63) |
| Preterm deliveryd | 21 (10.1) | 14 (8.5) | 1.31 (0.81,2.10) | 22 (12.1) | 11 (8.0) | 1.54 (1.35,1.75) |
| Ectopicd | 6 (2.9) | 3 (1.8) | 1.57 (0.41,5.95) | 7 (3.9) | 1 (0.7) | 6.00 (0.45,78.3) |
| Infertility | ||||||
| No | 757 (95.3) | 448 (95.5) | 345 (91.0) | 246 (88.2) | ||
| Yes | 37 (4.7) | 21 (4.5) | 1.53 (0.92,2.53) | 34 (9.0) | 33 (11.8) | 0.85 (0.56, 1.29) |
| Sought medical help for infertility | ||||||
| No | 764 (96.2) | 449 (95.7) | 336 (88.4) | 253 (90.7) | ||
| Yes | 30 (3.8) | 20 (4.3) | 1.38 (0.83,2.28) | 44 (11.6) | 26 (9.3) | 1.49 (0.89,2.49) |
Abbreviations: DES, diethylstilbestrol; PR, prevalence ratios; RR, risk ratios; CI, confidence intervals.
a
For outcomes prevalent at baseline, adjusted for age and cohort.
b
For new events occurring during follow-up, adjusted for age and cohort.
c
All pregnancy outcomes assessed among women who were ever pregnant.
d
The denominator for calculating percents is the number of women ever pregnant.