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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: J Immunol. 2019 Jan 25;202(5):1510–1520. doi: 10.4049/jimmunol.1801145

Figure 4. Gαi2 signaling is a critical determinant of macrophage pro-inflammatory (M1) vs anti-inflammatory (M2) phenotype.

Figure 4.

A) Expression of M1 genes in Gαi2 deficient BMDMs after treatment with LPS (1 μg/ml) for 4 hours. B) Expression of M2 genes in Gαi2 deficient BMDMs after treatment with IL-4 (20 ng/ml) for 48 hours. C) Expression of M1 genes in G184S KI BMDMs after treatment with LPS (1 μg/ml) for 4 hours. D) Expression of M2 genes in G184S KI BMDMs after treatment with IL-4 (20 ng/ml) for 48 hours. Data is presented as fold change relative to the WT control. Experiments were conducted at least 3 times in triplicate. P values were determined using Student’s t-test and p < 0.05 considered statistically significant (* p <0.05; ** p<0.005, *** p<0.001).