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. Author manuscript; available in PMC: 2020 Mar 15.
Published in final edited form as: Hear Res. 2019 Jan 23;374:24–34. doi: 10.1016/j.heares.2019.01.019

Fig. 2.

Fig. 2.

Auditory brainstem response (ABR) wave 1 amplitude as a function of click presentation level (A). Data are from before (black) and ≥4 weeks following (red) bilateral exposure to kainic acid (KA). KA reduces wave 1 amplitude at moderate to high sound levels by 40–70% across animals. The dashed black line drawn for K6 indicates mean wave-1 amplitude prior to KA in the other animals because pre-exposure control data were unavailable. Change over time in ABR wave 1 amplitude following KA exposure (B). Click level was 80 dB peak equivalent (p.e.) SPL. KA exposure causes long term reduction of wave 1, consistent with permanent auditory nerve (AN) injury.