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. Author manuscript; available in PMC: 2019 Dec 14.
Published in final edited form as: Mol Psychiatry. 2018 Aug 20;25(1):194–205. doi: 10.1038/s41380-018-0217-z

Figure 3: Altered gene expression patterns in cells with DISC1 607 Phe/Phe variant during T. gondii infection.

Figure 3:

A. Heat map of the mRNAs that were changed more than 1.5-fold upon T. gondii infection in DISC1 607 Leu/Leu cells. B. Heat map of the mRNAs that were changed more than 1.5-fold upon T. gondii infection in DISC1 607 Phe/Phe lymphoblastoid cells. Data were normalized and plotted on a log2 color scale. Welch t-test (unpaired and unequal variance) was used to select differentially expressed genes between two groups with p<0.05. Expression pattern similarity was visualized by hierarchical clustering with Euclidean as distance metric and Centroid as linkage rule. C. Venn diagram indicating overlap of gene expression changes upon T. gondii infection in DISC1 607 Leu/Leu and Phe/Phe lymphoblastoid cells. D. Ontology profiling of genes that are changed upon T. gondii infection in DISC1 607 Leu/Leu and Phe/Phe lymphoblastoid cells. Genes listed in A and B were analyzed using DAVID Bioinformatics Database (http://david.abcc.ncifcrf.gov/).