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. Author manuscript; available in PMC: 2019 Dec 14.
Published in final edited form as: Mol Psychiatry. 2018 Aug 20;25(1):194–205. doi: 10.1038/s41380-018-0217-z

Figure 5: Levels of anti-T. gondii IgG in serum from individuals with specific DISC1 SNP genotypes.

Figure 5:

A. Human DISC1 gene and known single nucleotide polymorphisms (SNPs). Human DISC1 gene covering exons 1 to 13 is shown, with the positions of SNPs and the haplotype blocks defined in a previous study 68, 69, 72, 73, 75. B. Increase in serum anti-T. gondii IgG levels in individuals with DISC1 607 Phe/Phe (n=17) compared to those with DISC1 607 Leu/Leu (n=490) or Leu/Phe genotype (n=143). Anti-T. gondii IgG levels in the serum were measured by ELISA. Error bars show s.e.m. *p<0.05, **p<0.01. C. No difference in serum anti-T. gondii IgG level among individuals with DISC1 704 Ser/Ser, Ser/Cys and Cys/Cys. D. Higher T. gondii seropositivity (antibody levels ≥10 units/mL) rate in individuals with DISC1 607 Phe/Phe genotype compared to those with DISC1 607 Leu/Leu. Note that T. gondii IgG levels were well predicted by DISC1 Phe/Phe in multinomial logistic regression analysis with age, gender, race, and disease diagnosis as variables (p=0.010) (Table 1). E. No difference in T. gondii seropositivity (antibody levels ≥10 units/mL) among individuals with DISC1 704 Ser/Ser, Ser/Cys and Cys/Cys. F. T. gondii seropositivity rate in another cohort (n=652). No individuals with DISC1 607 Phe/Phe (n=11) showed increase in serum anti-T. gondii IgG levels.