Table 3.
Regional Ganglion Cell Complex Thickness and Vessel Density in Healthy, Pre-perimetric Glaucoma and Early Glaucoma Eyes: Univariate and Multivariate Analysis
| Mean (95% Confidence Interval) |
P value (univariate, multivariate) |
|||||
|---|---|---|---|---|---|---|
| A. Healthy | B. Pre-perimetric Glaucoma |
C. Early Glaucoma |
A vs. B | B vs. C | A vs. C | |
| Ganglion Cell Complex Thickness (μm) | ||||||
| Superior Hemifield of Whole Image | 103.2 (101.7, 104.8) | 98.0 (95.4, 100.6) | 94.4 (92.7, 96.1) | 0.006, 0.008 | 0.055, 0.066 | <.0001, <.0001 |
| Inferior Hemifield of Whole Image | 103.5 (101.8, 105.2) | 99.1 (96.5, 101.6) | 91.8 (89.5, 94.0) | 0.021, 0.012 | <.0001, <.0001 | <.0001, <.0001 |
| Superior Hemifield of perifoveal | 108.7 (107.0, 110.3) | 103.4 (100.6, 106.2) | 99.5 (97.7, 101.3) | 0.011, 0.013 | 0.051, 0.059 | <.0001, <.0001 |
| Inferior Hemifield of perifoveal | 109.22 (107.51, 110.94) | 104.7 (102.0, 107.4) | 96.9 (94.5, 99.3) | 0.027, 0.013 | <.0001, <.0001 | <.0001, <.0001 |
| Temporal perifoveal | 102.1 (100.4, 103.7) | 97.9 (95.3, 100.4) | 90.1 (88.1, 92.0) | 0.028, 0.007 | <.0001, <.0001 | <.0001, <.0001 |
| Superior perifoveal | 112.0 (110.2, 113.9) | 105.7 (102.6, 108.7) | 102.4 (100.4, 104.5) | 0.004, 0.006 | 0.131, 0.169 | <.0001, <.0001 |
| Nasal perifoveal | 109.7 (108.0, 111.4) | 105.8 (103.0, 108.6) | 101.8 (99.8, 103.7) | 0.066, 0.070 | 0.053, 0.054 | <.0001, <.0001 |
| Inferior perifoveal | 111.9 (110.0, 113.8) | 106.8 (104.0, 109.6) | 98.5 (95.7, 101.2) | 0.018, 0.013 | <.0001, <.0001 | <.0001, <.0001 |
| Vessel density (%) | ||||||
| Superior Hemifield of Whole Image | 48.0 (47.4, 48.7) | 45.6 (44.9, 46.4) | 44.9 (44.3, 45.5) | <.0001, 0.004 | 0.161, 0.404 | <.0001, <.0001 |
| Inferior Hemifield of Whole Image | 47.8 (47.2, 48.4) | 45.4 (44.5, 46.3) | 44.2 (43.5, 45.0) | <.0001, 0.002 | 0.058, 0.103 | <.0001, <.0001 |
| Superior Hemifield of perifoveal | 50.7 (50.0, 51.3) | 48.1 (47.3, 49.0) | 47.6 (47.0, 48.2) | <.0001, 0.003 | 0.312, 0.663 | <.0001, <.0001 |
| Inferior Hemifield of perifoveal | 50.5 (49.9, 51.1) | 48.1 (47.2, 49.0) | 46.9 (46.1, 47.7) | <.0001, 0.002 | 0.056, 0.098 | <.0001, <.0001 |
| Temporal perifoveal | 49.5 (48.9, 50.2) | 46.9 (46.1, 47.7) | 46.0 (45.3, 46.7) | <.0001, 0.001 | 0.098, 0.143 | <.0001, <.0001 |
| Superior perifoveal | 51.6 (50.8, 52.4) | 49.0 (48.1, 49.9) | 48.6 (48.0, 49.3) | <.0001, 0.007 | 0.517, 0.961 | <.0001, 0.002 |
| Nasal perifoveal | 49.9 (49.2, 50.7) | 47.9 (47.0, 48.7) | 47.0 (46.3, 47.7) | 0.001, 0.038 | 0.124, 0.298 | <.0001, 0.001 |
| Inferior perifoveal | 51.3 (50.6, 52.0) | 48.7 (47.7, 49.7) | 47.5 (46.6, 48.4) | <.0001, 0.001 | 0.065, 0.132 | <.0001, <.0001 |
Age, gender, race, self-reported diabetes and hypertension, and scan quality were adjusted for multivariate analysis. Values with statistical significance are shown in bold.