Table 5.
Percent Loss of Regional Ganglion Cell Complex Thickness and Vessel Density in Pre-perimetric Glaucoma and Early Glaucoma Eyes: Univariate and Multivariate Analysis
| Percent Loss | Thickness (%) | Vessel Density (%) |
P value (univariate, multivariate) |
|---|---|---|---|
| Superior Hemifield of Whole Image | |||
| Pre-perimetric Glaucoma | 5.1 (2.5, 7.6) | 5.0 (3.3, 6.6) | 0.943, 0.945 |
| Early Glaucoma | 8.6 (6.9, 10.2) | 6.5 (5.3, 7.8) | 0.026, 0.028 |
| P value (univariate, multivariate) | 0.055, 0.065 | 0.161, 0.446 | |
| Inferior Hemifield of Whole Image | |||
| Pre-perimetric Glaucoma | 4.3 (1.9, 6.8) | 5.0 (3.1, 6.9) | 0.637, 0.645 |
| Early Glaucoma | 11.4 (9.2, 13.6) | 7.5 (5.9, 9.0) | <.0001, <.0001 |
| P value (univariate, multivariate) | <.001, <.0001 | 0.058, 0.113 | |
| Superior Hemifield of Perifoveal | |||
| Pre-perimetric Glaucoma | 4.8 (2.2, 7.4) | 5.0 (3.4, 6.6) | 0.908, 0.910 |
| Early Glaucoma | 8.4 (6.7, 10.1) | 6.1 (4.9, 7.3) | 0.015, 0.016 |
| P value (univariate, multivariate) | 0.051, 0.057 | 0.312, 0.708 | |
| Inferior Hemifield of Perifoveal | |||
| Pre-perimetric Glaucoma | 4.2 (1.7, 6.6) | 4.7 (2.9, 6.5) | 0.703, 0.710 |
| Early Glaucoma | 11.3 (9.1, 13.5) | 7.1 (5.5, 8.7) | <.0001, <.0001 |
| P value (univariate, multivariate) | <.001, <.0001 | 0.056, 0.108 | |
| Temporal Perifoveal | |||
| Pre-perimetric Glaucoma | 4.2 (1.6, 6.7) | 5.3 (3.7, 6.9) | 0.398, 0.409 |
| Early Glaucoma | 11.8 (9.9, 13.7) | 7.2 (5.7, 8.6) | <.0001, <.0001 |
| P value (univariate, multivariate) | <.001, <.0001 | 0.098, 0.150 | |
| Superior Perifoveal | |||
| Pre-perimetric Glaucoma | 5.7 (3.0, 8.4) | 5.0 (3.2, 6.8) | 0.634, 0.642 |
| Early Glaucoma | 8.6 (6.8, 10.4) | 5.7 (4.4, 7.0) | 0.005, 0.006 |
| P value (univariate, multivariate) | 0.131, 0.167 | 0.517, 0.998 | |
| Nasal Perifoveal | |||
| Pre-perimetric Glaucoma | 3.5 (1.0, 6.1) | 4.1 (2.4, 5.8) | 0.731, 0.737 |
| Early Glaucoma | 7.2 (5.5, 9.0) | 5.9 (4.2, 7.4) | 0.196, 0.201 |
| P value (univariate, multivariate) | 0.053, 0.053 | 0.124, 0.327 | |
| Inferior Perifoveal | |||
| Pre-perimetric Glaucoma | 4.5 (2.0, 7.1) | 5.1 (3.1, 7.0) | 0.733, 0.739 |
| Early Glaucoma | 12.0 (9.6, 14.4) | 7.5 (5.7, 9.3) | <.0001, <.0001 |
| P value (univariate, multivariate) | <.001, <.0001 | 0.065, 0.145 | |
Percent loss, which was calculated as [1-( raw measurement / mean value of healthy eyes)]×100 (%), are shown in mean (95% confidence interval). Values with statistical significance are shown in bold. Multivariate analysis adjusted for age, gender, race, self-reported diabetes and hypertension, and scan quality.