Table 1.

Inhibitory effects of berberine on tumor migration and invasion.

Cell lines	Mechanism	Reference
Human non-small cell lung cancer (A549)	N-Cadherin↓ E-cadherin↑	Li et al., 2018
Hepatocellular carcinoma (HCC) cells	COX-2↓,NF-κB↓ UPA,MMP-9↓	Sengupta et al., 2017
Endothelial canjcer colon cells	IL-8↓, NF-κB↓ AMPK↑	Li et al., 2014
Mouse melanoma cell (B16F-10)	VEGF mRNA↓	Siveen and Kuttan, 2011; Hamsa and Kuttan, 2011
Human umbilical vein endothelial cells (HUVEC)	COX-2↓, iNOS↓, VEGF mRNA↓	Ma et al., 2008
Human endometrial cancer cell lines(AN3 CA and HEC-1-A)	COX-2↓ PEG-2↓	Wu et al., 2012