Table 2.

Inhibitory effects of berberine on tumor cell proliferation.

Cell Lines	Mechanism	Reference
Liver cancer cells	Caspase-3↑, Caspase-8↑,PARP↑	Mistry et al., 2017
Human ovarian cancer cell (SKOV3)	Bcl-2↓ Bax↑, Cleaved-Caspase-3↑,	Su et al., 2015
Colorectal adenocarcinoma cell line (HCT-15)	EGFR↓, Bcl-2↓, Survivin↓ ATG5↑, Bax↑, LC3↑	Agnarelli et al., 2018
Human cervical cancer cell (CaSki)	p53↑, Bax/Bcl-2↑ ROS↑, Caspase-3↑	Kalaiarasi et al., 2016
Human bladder cancer cell (BIU-87, T24)	Caspase-3↑, Caspase-9↑	Lu et al., 2015
Human pancreatic carcinoma cell (MIA PaCa-2)	Caspase-3↑ P53↓	Katona et al., 2014